In general app-crypt/tpm2-tss can be built with either mbedtls or openssl, but USE=fapi only supports openssl. It would be nice to have a libressl alternative for that case, if it is possible.
Not up to me but feel can safely say it's not happening. https://github.com/tpm2-software/tpm2-tss/issues/1235
Turn out libressl now supports the required functions since 3.0.2: https://github.com/libressl-portable/portable/issues/547 . After editing the ebuild, tpm2-tss seems to build just fine using libressl and the "fapi" flag, so I see no reason not to allow it.
Nice that it's possible, but given seems bug #762847 will go forward it'll be short lived.
Created attachment 683935 [details, diff] Add libressl support
Created attachment 683938 [details, diff] Add libressl support
Given that libressl is on its way out, there seems to be little point in adding support, however, I will include the patches needed here so the can used in an overlay or submitted upstream.