Compiling wine on amd64 requires much, much tweaking of the system and build environment. I still haven't gotten it to work. Right now I'm working on getting a 32-bit libglut. Wine doesn't even come close to being ready for prime time on ~amd64.
Steps to Reproduce:
1. Run ~amd64
2. emerge wine
massive failures of many descriptions. See bug 82758.
Either not tried to emerge, or emerged successfully.
Wine ebuild on amd64 will eventually be possible via multilib. However, this
will not be the case for a long while.
hmm... After seeing further progress on bug 82758, perhaps it will be sooner than I predicted. However, ~amd64 should be removed until both the wine ebuild and its dependencies are fixed to allow it.
As was stated by the wine maintainer in bug #82758 the current ebuilds should now work ok. If you are still having issues with the latest ebuild then I suggest that you file a bug stating the issue/error so that the problem can be resolved.