Hi, I'm on a no-multilib ~amd64 Gentoo, and I tried to emerge snes9x, modifing the ebuild to remove the multilib, and it seems to compile and run fine. I compiled it with the opengl and zlib useflags, but I didn't test with the others flags. It may requires more testing from other users to confirm it, but I think we can remove the multilib requirement from the ebuild and unmask it for the no-multilib amd64 systems.
Created attachment 159469 [details] emerge --info emerge --info for more information on my setup
Created attachment 159470 [details, diff] snes9x-amd64.diff ebuild patch to remove the multilib requirement
should be fixed with inclusion of 1.52