wxwidgets has a compile time depenacy on xineramas headers, the headers arnt installed as part of x when using modular X x11-proto/xineramaproto contains the headers.
sp. :(
Reopen with some errors and emerge --info.
wxPython-src-2.6.3.2 from the tarball src/unix/displayx11.cpp line 41 #include <X11/extensions/Xinerama.h>
It should be possible to omit xinerama support. I will have to look what happens to symbol availability of the wxDisplay class when xinerama headers aren't provided, and what apps, if any, depend on wxDisplay in a manner that would break without xinerama support in wx. Other X headers that are used by wxGTK in src/unix/displayx11.cpp, fontenum.cpp, fontutil.cpp, taskbarx11.cpp, utilsx11.cpp, and src/gtk/combobox.cpp, settings.cpp, spinctrl.cpp, toplevel.cpp, utilsgtk.cpp, win_gtk.c : x11-proto/xf86vidmodeproto (/usr/include/X11/extensions/xf86vmode.h) x11-proto/xproto (/usr/include/X11/{keysym.h,Xatom.h}) x11-proto/xineramaproto (/usr/include/X11/extensions/Xinerama.h) x11-libs/libX11 (/usr/include/X11/{Xlibint.h,Xutil.h,Xlib.h})
xproto, xineramaproto, xf86vidmodeproto DEPENDs and libXinerama, libXxf86vm, libgnomeprintui RDEPENDs added as appropriate in 2.6.3.3. Thanks for noticing the problem!