Compiling wine on amd64 requires much, much tweaking of the system and build environment. I still haven't gotten it to work. Right now I'm working on getting a 32-bit libglut. Wine doesn't even come close to being ready for prime time on ~amd64. Reproducible: Always Steps to Reproduce: 1. Run ~amd64 2. emerge wine Actual Results: massive failures of many descriptions. See bug 82758. Expected Results: Either not tried to emerge, or emerged successfully. Wine ebuild on amd64 will eventually be possible via multilib. However, this will not be the case for a long while.
hmm... After seeing further progress on bug 82758, perhaps it will be sooner than I predicted. However, ~amd64 should be removed until both the wine ebuild and its dependencies are fixed to allow it.
As was stated by the wine maintainer in bug #82758 the current ebuilds should now work ok. If you are still having issues with the latest ebuild then I suggest that you file a bug stating the issue/error so that the problem can be resolved.