The ebuild includes a patch - radeon-profile-daemon-20190603-run_subdir.patch that places the daemon's socket file in a /var/run subirectory. This directory is not created when starting the systemd unit for the daemon. Adding RuntimeDirectory=radeon-profile-daemon to the systemd unit fixes the issue. Reproducible: Always Steps to Reproduce: 1. Emerge radeon-profile and radeon-profile-daemon on systemd machine 2. Run the daemon and the user program. 3. The user program won't be able to connect to the daemon. [~]>emerge --info Portage 3.0.8 (python 3.7.9-final-0, default/linux/amd64/17.1/desktop/plasma/systemd, gcc-9.3.0, glibc-2.32-r2, 5.9.0 x86_64) ================================================================= System uname: Linux-5.9.0-x86_64-Intel-R-_Core-TM-_i9-9900K_CPU_@_3.60GHz-with-gentoo-2.7 KiB Mem: 65783516 total, 35305752 free KiB Swap: 0 total, 0 free Timestamp of repository dotnet: Thu, 15 Oct 2020 20:05:11 +0000 Head commit of repository dotnet: 53f16aaf48bbb898741c4c8ab7deb7b53753f62f Timestamp of repository farmboy0: Tue, 29 Sep 2020 14:07:35 +0000 Head commit of repository farmboy0: 8f532b7e0301381efc9d74606a7e9b35983525ac Timestamp of repository guru: Tue, 27 Oct 2020 18:35:15 +0000 Head commit of repository guru: 78f55bd19d54d4e4e0b8fd4abae18445af7cec7d Timestamp of repository haskell: Sat, 31 Oct 2020 14:05:21 +0000 Head commit of repository haskell: c7c84dd7970628830564580f8b9f50679a79b804 Timestamp of repository jorgicio: Sat, 31 Oct 2020 15:35:13 +0000 Head commit of repository jorgicio: 6cc2eca60c5c10a832006237d2793cdd4e69f261 Head commit of repository nvidia-vulkan: 9e4cdb59aa431f9d70c69cdc6aaec7b3dc2615ee Timestamp of repository trolltoo: Tue, 29 Sep 2020 14:07:51 +0000 Head commit of repository trolltoo: fca52b677e0da2ad14ad864b369080f836f29e31 Timestamp of repository vapoursynth: Sun, 25 Oct 2020 23:35:17 +0000 Head commit of repository vapoursynth: 1834708bb0d697bb63ac0079582bbde43cafb218 Timestamp of repository vowstar: Sun, 25 Oct 2020 02:05:19 +0000 Head commit of repository vowstar: 37a1c8b9bfa5c305e0d0c6d2e980180540b016f8 Timestamp of repository gentoo: Sat, 31 Oct 2020 17:15:01 +0000 Head commit of repository gentoo: 94b280a2afcff206e7bf5e82c5dcf775eee8ee8e Head commit of repository steam-overlay: 32f27e07e540110458c069965e8e027d7350fbd8 Head commit of repository kwin-lowlatency-overlay: 4d0b9293bb3b293a58a856ad2b5295a737e34806 sh bash 5.0_p18 ld GNU ld (Gentoo 2.33.1 p2) 2.33.1 distcc 3.3.3 x86_64-pc-linux-gnu [disabled] ccache version 3.7.11 [disabled] app-shells/bash: 5.0_p18::gentoo dev-java/java-config: 2.3.1::gentoo dev-lang/perl: 5.30.3::gentoo dev-lang/python: 2.7.18-r4::gentoo, 3.6.11-r2::gentoo, 3.7.9::gentoo, 3.8.5::gentoo dev-util/ccache: 3.7.11::gentoo dev-util/cmake: 3.18.4::gentoo dev-util/pkgconfig: 0.29.2::gentoo sys-apps/baselayout: 2.7::gentoo sys-apps/sandbox: 2.18::gentoo sys-devel/autoconf: 2.13-r1::gentoo, 2.69-r5::gentoo sys-devel/automake: 1.14.1-r2::gentoo, 1.16.1-r1::gentoo sys-devel/binutils: 2.33.1-r1::gentoo, 2.34-r2::gentoo sys-devel/gcc: 9.3.0-r1::gentoo sys-devel/gcc-config: 2.3.2::gentoo sys-devel/libtool: 2.4.6-r6::gentoo sys-devel/make: 4.2.1-r4::gentoo sys-kernel/linux-headers: 5.4-r1::gentoo (virtual/os-headers) sys-libs/glibc: 2.32-r2::gentoo Repositories: crossdev location: /var/portage/repositories/crossdev masters: gentoo dotnet location: /var/portage/repositories/dotnet sync-type: git sync-uri: https://github.com/gentoo-mirror/dotnet.git masters: gentoo farmboy0 location: /var/portage/repositories/farmboy0 sync-type: git sync-uri: https://github.com/gentoo-mirror/farmboy0.git masters: gentoo guru location: /var/portage/repositories/guru sync-type: git sync-uri: https://github.com/gentoo-mirror/guru.git masters: gentoo haskell location: /var/portage/repositories/haskell sync-type: git sync-uri: https://github.com/gentoo-mirror/haskell.git masters: gentoo jorgicio location: /var/portage/repositories/jorgicio sync-type: git sync-uri: https://github.com/gentoo-mirror/jorgicio.git masters: gentoo localmaint location: /var/portage/repositories/local masters: gentoo priority: 0 nvidia-vulkan location: /var/portage/repositories/nvidia-vulkan sync-type: git sync-uri: https://github.com/kakra/nvidia-vulkan.git masters: gentoo trolltoo location: /var/portage/repositories/trolltoo sync-type: git sync-uri: https://github.com/gentoo-mirror/trolltoo.git masters: gentoo vapoursynth location: /var/portage/repositories/vapoursynth sync-type: git sync-uri: https://github.com/gentoo-mirror/vapoursynth.git masters: gentoo vowstar location: /var/portage/repositories/vowstar sync-type: git sync-uri: https://github.com/gentoo-mirror/vowstar.git masters: gentoo gentoo location: /auto/portage sync-type: rsync sync-uri: rsync://rsync.us.gentoo.org/gentoo-portage/ priority: 1 sync-rsync-extra-opts: sync-rsync-verify-max-age: 24 sync-rsync-verify-metamanifest: yes sync-rsync-verify-jobs: 1 steam-overlay location: /var/portage/repositories/steam sync-type: git sync-uri: https://github.com/anyc/steam-overlay.git masters: gentoo priority: 50 kwin-lowlatency-overlay location: /var/portage/repositories/kwin-lowlatency-overlay sync-type: git sync-uri: https://github.com/agates/kwin-lowlatency-overlay.git masters: gentoo priority: 9999 ACCEPT_KEYWORDS="amd64" ACCEPT_LICENSE="@FREE" CBUILD="x86_64-pc-linux-gnu" CFLAGS="-march=skylake -O2 -pipe" CHOST="x86_64-pc-linux-gnu" CONFIG_PROTECT="/etc /usr/lib64/libreoffice/program/sofficerc /usr/share/config /usr/share/gnupg/qualified.txt /usr/share/themes/oxygen-gtk/gtk-2.0" CONFIG_PROTECT_MASK="/etc/ca-certificates.conf /etc/dconf /etc/env.d /etc/fonts/fonts.conf /etc/gconf /etc/gentoo-release /etc/revdep-rebuild /etc/sandbox.d /etc/terminfo /etc/texmf/language.dat.d /etc/texmf/language.def.d /etc/texmf/updmap.d /etc/texmf/web2c" CXXFLAGS="-march=skylake -O2 -pipe" DISTDIR="/auto/distfiles" ENV_UNSET="CARGO_HOME DBUS_SESSION_BUS_ADDRESS DISPLAY GOBIN GOPATH PERL5LIB PERL5OPT PERLPREFIX PERL_CORE PERL_MB_OPT PERL_MM_OPT XAUTHORITY XDG_CACHE_HOME XDG_CONFIG_HOME XDG_DATA_HOME XDG_RUNTIME_DIR" FCFLAGS="-O2 -pipe" FEATURES="assume-digests binpkg-docompress binpkg-dostrip binpkg-logs config-protect-if-modified distlocks ebuild-locks fixlafiles ipc-sandbox merge-sync multilib-strict network-sandbox news parallel-fetch pid-sandbox preserve-libs protect-owned qa-unresolved-soname-deps sandbox sfperms strict unknown-features-warn unmerge-logs unmerge-orphans unprivileged userfetch userpriv usersandbox usersync" FFLAGS="-O2 -pipe" GENTOO_MIRRORS="http://gentoo.osuosl.org/" LANG="en_US.utf-8" LDFLAGS="-Wl,-O1 -Wl,--as-needed" MAKEOPTS="-j16 -l16" PKGDIR="/var/cache/binpkgs" PORTAGE_CONFIGROOT="/" PORTAGE_RSYNC_OPTS="--recursive --links --safe-links --perms --times --omit-dir-times --compress --force --whole-file --delete --stats --human-readable --timeout=180 --exclude=/distfiles --exclude=/local --exclude=/packages --exclude=/.git" PORTAGE_TMPDIR="/var/tmp" USE="X a52 aac acl acpi activities alsa amd64 amr berkdb bluetooth branding bzip2 cairo cdda cdr cjk cli crypt cups dbus declarative dri dts dvd dvdr emboss emul-linux-x86 encode exif fam ffmpeg flac fortran gcj gdbm gif gnutls gpm gui handbook iconv icu ipv6 jpeg kde kipi kwallet lcms libglvnd libnotify libtirpc mad matroska mmx mng mp3 mp4 mpeg multilib ncurses nls nptl nptlonly ogg opengl openmp pam pango pcre pdf phonon plasma png policykit ppds pulseaudio qml qt5 readline sdl seccomp semantic-desktop speex spell split-usr sqlite3 sse sse2 ssl startup-notification svg systemd tcpd theora tiff truetype udev udisks unicode upower usb vdpau vorbis wayland widgets wxwidgets x264 xattr xcb xinerama xml xv xvid zlib" ABI_X86="64" ADA_TARGET="gnat_2018" ALSA_CARDS="ali5451 als4000 atiixp atiixp-modem bt87x ca0106 cmipci emu10k1x ens1370 ens1371 es1938 es1968 fm801 hda-intel intel8x0 intel8x0m maestro3 trident usb-audio via82xx via82xx-modem ymfpci" APACHE2_MODULES="authn_core authz_core socache_shmcb unixd actions alias auth_basic authn_alias authn_anon authn_dbm authn_default authn_file authz_dbm authz_default authz_groupfile authz_host authz_owner authz_user autoindex cache cgi cgid dav dav_fs dav_lock deflate dir disk_cache env expires ext_filter file_cache filter headers include info log_config logio mem_cache mime mime_magic negotiation rewrite setenvif speling status unique_id userdir usertrack vhost_alias" CALLIGRA_FEATURES="karbon sheets words" COLLECTD_PLUGINS="df interface irq load memory rrdtool swap syslog" CPU_FLAGS_X86="mmx mmxext sse sse2 aes avx avx2 f16c fma3 pclmul popcnt sse3 sse4_1 sse4_2 ssse3" ELIBC="glibc" GPSD_PROTOCOLS="ashtech aivdm earthmate evermore fv18 garmin garmintxt gpsclock greis isync itrax mtk3301 nmea ntrip navcom oceanserver oldstyle oncore rtcm104v2 rtcm104v3 sirf skytraq superstar2 timing tsip tripmate tnt ublox ubx" INPUT_DEVICES="libinput" KERNEL="linux" LCD_DEVICES="bayrad cfontz cfontz633 glk hd44780 lb216 lcdm001 mtxorb ncurses text" LIBREOFFICE_EXTENSIONS="presenter-console presenter-minimizer" LUA_SINGLE_TARGET="lua5-1" LUA_TARGETS="lua5-1" OFFICE_IMPLEMENTATION="libreoffice" PHP_TARGETS="php7-2 php7-3 php7-4" POSTGRES_TARGETS="postgres10 postgres11" PYTHON_SINGLE_TARGET="python3_7" PYTHON_TARGETS="python2_7 python3_7" RUBY_TARGETS="ruby26" USERLAND="GNU" VIDEO_CARDS="amdgpu intel radeonsi i965 iris" XTABLES_ADDONS="quota2 psd pknock lscan length2 ipv4options ipset ipp2p iface geoip fuzzy condition tee tarpit sysrq steal rawnat logmark ipmark dhcpmac delude chaos account" Unset: CC, CPPFLAGS, CTARGET, CXX, EMERGE_DEFAULT_OPTS, INSTALL_MASK, LC_ALL, LINGUAS, PORTAGE_BINHOST, PORTAGE_BUNZIP2_COMMAND, PORTAGE_COMPRESS, PORTAGE_COMPRESS_FLAGS, PORTAGE_RSYNC_EXTRA_OPTS