libffi-3.3 had minor API changes like https://github.com/libffi/libffi/commit/ef76205647bca77796882d31f6ab5e889f461f07 This is a tracker bug. No talking here please. Let's gather typical failures and examples of fixes at: https://wiki.gentoo.org/wiki/Project:Toolchain#libffi-3.3
The breakage was not as widespread as I initially thought. Closing the tracker.