Created attachment 696972 [details] script which prints packages names of linked libraries i checked this package with attached script (deplibs dev-python/pycryptodome) and it returns: dev-libs/libtomcrypt:0: sys-libs/musl:0: also dev-libs/gmp is optional DEPEND for dev-libs/libtomcrypt
Created attachment 696975 [details, diff] patch to remove dev-libs/gmp DEPEND
It definitely tries to use GMP if available using ffi: https://github.com/Legrandin/pycryptodome/blob/99b297f73110396b8dcd1c5eb0e187676e2c530e/lib/Crypto/Math/_IntegerGMP.py.