irqbalance has ARM support as of version 1.1.0 , over 4 years ago, and ARM64 support as of version 1.2.0 , over 3 years ago. I've been using it without problem on my pinebook-pro, and it deals with the big.little topology just fine.
commit 19edc4f25cd8ae107c91d110212cab5506bd975b Author: Sam James (sam_c) <sam@cmpct.info> Date: Thu May 21 10:38:37 2020 +0000 sys-apps/irqbalance: arm64 keyworded (bug #721536)
~arm added, closing