Per: https://bugs.debian.org/cgi-bin/bugreport.cgi?bug=757429 with current wxpython3 versions, playonlinux should work ok. Could that be tried? Thanks!
Also per: https://www.playonlinux.com/en/issue-4841.html
[master b257603c6fb] app-emulation/playonlinux: Version bump, use wxpython-3.0 (#601092) and allow virtual/wine usage (#619500 by adebeus). 2 files changed, 117 insertions(+) create mode 100644 app-emulation/playonlinux/playonlinux-4.2.11.ebuild