Some of the sections in the default config file don't work anymore (in my case, serialports). It needs updating. See http://bugs.winehq.org/show_bug.cgi?id=2402
The sample 20040716 config can be found here: http://cvs.winehq.com/cvsweb/wine/documentation/samples/config
20041019-r1 patches the config file that comes in the current version and uses that