I have seen a lot of ebuilds relying on wxpython but not using the eclass, should it be used or not? In the eclass comments it looks to be for wxGTK consumers, but nothing is specified for wxpython Thanks
Nope, the eclass is for packages to control the version of the wxGTK libs to build against by wrapping wx-config. wxpython-using packages don't link to those libs and don't use wx-config. I'll add a comment.
Added.