Without python USE flag the /usr/share/system-config-printer/applet.py fails on import cups.
The ebuild depends on pycups which provides python cups module.
(In reply to Gilles Dartiguelongue from comment #1) > The ebuild depends on pycups which provides python cups module. Hmm. Then it should depend on pycups with PYTHON_TARGETS="python2*".
1.4.1 uses python-single-r1 which would fix any python dependency problem. Could you tell us if it fixes your issue ?
WFM