Please add amd64 to the KEYWORDS for dev-python/wxPython-2.4.2.4. This package is used by bittorrent, which also works (I have already made a report for bittorrent). Reproducible: Always Steps to Reproduce: Portage 2.0.50-r1 (default-amd64-2004.0, gcc-3.3.3, glibc-2.3.2-r9, 2.6.4-gentoo) ================================================================= System uname: 2.6.4-gentoo x86_64 4 Gentoo Base System version 1.4.3.13 Autoconf: sys-devel/autoconf-2.58-r1 Automake: sys-devel/automake-1.7.8 ACCEPT_KEYWORDS="amd64" AUTOCLEAN="yes" CFLAGS="-O2 -pipe" CHOST="x86_64-pc-linux-gnu" COMPILER="gcc3" CONFIG_PROTECT="/etc /usr/X11R6/lib/X11/xkb /usr/kde/2/share/config /usr/kde/3.2/share/config /usr/kde/3/share/config /usr/lib/mozilla/defaults/pref /usr/share/config /var/qmail/control" CONFIG_PROTECT_MASK="/etc/gconf /etc/terminfo /etc/env.d" CXXFLAGS="-O2 -pipe" DISTDIR="/usr/portage/distfiles" FEATURES="autoaddcvs ccache sandbox" GENTOO_MIRRORS="http://gentoo.noved.org/ http://mirrors.tds.net/gentoo http://mirror.tucdemonic.org/gentoo/ http://adelie.polymtl.ca/" MAKEOPTS="-j2" PKGDIR="/usr/portage/packages" PORTAGE_TMPDIR="/var/tmp" PORTDIR="/usr/portage" PORTDIR_OVERLAY="" SYNC="rsync://rsync.gentoo.org/gentoo-portage" USE="X aalib alsa amd64 apache2 apm arts avi berkdb cdr crypt cups dvd dvdr encode foomaticdb gdbm gif gnome gpm gtk gtk2 gtkhtml imlib ipv6 java jpeg libg++ libwww mikmod motif mozilla mpeg multilib mysql ncurses nls oggvorbis opengl oss pam pdflib perl png ppds python quicktime readline samba sdl slang spell ssl tcpd tiff truetype unicode usb videos x xml xml2 xmms xv zlib"
dev-python/wxPython-2.4.2.4 has the ~amd64 KEYWORD