When running python-updater, it wants to rebuild app-emulation/virtualbox-4.1.8 over and over again. I have python 2.6, 2.7 (eselected) and 3.2 installed. VirtualBox seems to recreate /usr/lib64/virtualbox/VBoxPython2_6.so, which (ldd says) links to /usr/lib64/libpython2.6.so.1.0. I don't know if there is something that can be changed (i.e. preventing virtualbox from knowing about py-2.6), but it's undesired behaviour that python-updater wants to do something during the second of two subsequent runs.
Created attachment 305567 [details, diff] virtualbox-bin-4.1.10.ebuild.patch
Should be fixed. I'll leave it to the maintainers to port to the older versions if they like. + 16 Mar 2012; Mike Gilbert <floppym@gentoo.org> virtualbox-bin-4.1.10.ebuild: + Set PYTHON_UPDATER_IGNORE and remove some obsolete entries in QA and RDEPEND + variables. Patch by Arfrever. Bug 405947.
All versions in portage have this fix now.