Dear CCPN users, We are pleased to announce the release of ARIA version 2.3. An archive containing the distribution can be downloaded from our server at http://aria.pasteur.fr The archive can be unpacked by using the command "tar xvzf aria2.3.1.tar.gz". For installation, please follow the instructions given in the README file provided with the distribution. Version 2.3 is an extension of the version 2.2 of the program and offers several new features. This version of ARIA is now compatible with the version 2 of CCPN software packages. A new log-harmonic potential for distance restraints has also been introduced. This potential allows for the determination of the optimal weight on the experimental information and the resulting structures are of better quality. To activate the use of this potential, go to "Structure Generation > CNS > Annealing Parameters > Log-Hamonic potential" in the ARIA Graphical user interface. Details on the log-harmonic potential can be found in the original publication: Nilges et al. Accurate NMR structures through minimization of an extended hybrid energy. Structure (2008) vol. 16 (9) pp. 1305-12 The integration of the CCPN has been completed, too. ARIA can now import structure models and structure ensembles from a CCPN project, and use them as either initial structure for the simulated annealing protocol, or as template structures for the initial assignment/calibration step. The data imported and exported in different ARIA2.3 runs can be followed in CcpNmr Analysis under the "NMR Calculations" menu. The calculation of symmetric homo-dimers has been also extended to trimers and pentamers with cyclic symmetry and also tetramers with dihedral symmetry. A list of additional new features can be found on the download page http://aria.pasteur.fr/downloads/ The ARIA team http://aria.pasteur.fr
