dev-tex/isotope-20040401 should be in the tree long enough by now. Have been using the package for more than a year (not very often), had no problems neither on amd64 nor x86. Current status is ~amd64,~x86, could probably be keyworded on other archs.
I agree, starting to get on top of some of the stabilization bugs now. Marked stable on amd64. It will not be marked stable on any other arches as it has not been in testing for them either. Request x86 care to stabilize too, please.
x86 stable, all arches done.