I just bumped inkscape with a jabber use-flag, which depends on net-libs/loudmouth and isn't keyworded hppa. So I dropped the hppa keyword from media-gfx/inkscape-0.45.1-r1 - please keyword loudmouth or mask the flag in your profile. (and rekeyword latest inkscape revision)
Fixed.
I would reopen this bug if I could... So, I will make a new bug. Inkscape 0.45.1 DOES NOT depend on loudmouth. The ebuild is incorrect to list this dependency.