roundup could be run as stand alone server or through mod_python/other cgi, it could use various db backend. Would be nice if useflags for the different db backends and apache (lighttpd?Zope?) support could be added. Probably just providing the right .htaccess would be already a nice with a minimal work.
can you post a sample .htaccess ?
sadly seems you can't enable mod_python from .htaccess http://roundup.sourceforge.net/doc-1.0/installation.html#apache-http-server-with-mod-python But since I'm not that proficient maybe I'm just wrong.
I don't see an easy solution to do this. We don't have any webapps that currently modify the apache settings. I know this would be sometimes useful but we shouldn't include to much magic. Closing for now but please fell free to reopen if you think there is a way to do this properly.