--- a/modules/wxwidgets.eselect	
+++ a/modules/wxwidgets.eselect	
@@ -1,15 +1,18 @@ 
 # -*-eselect-*-  vim: ft=eselect
-# Copyright 1999-2014 Gentoo Foundation
+# Copyright 1999-2018 Gentoo Foundation
 # Distributed under the terms of the GNU General Public License v2
 
-inherit config
+inherit config multilib
 
 DESCRIPTION="Manage the system default wxWidgets profile"
 MAINTAINER="wxwidgets@gentoo.org"
 VERSION="20140423"
 
 WXCONFFILE="${EROOT}"/var/lib/wxwidgets/current
-WXCONFDIR="${EROOT}"/usr/lib/wx/config
+
+get_confdir() {
+	echo "${EROOT}/usr/$(get_libdir)/wx/config"
+}
 
 find_targets() {
 	local conf
@@ -89,6 +92,7 @@ describe_list() {
 }
 
 do_list() {
+	local WXCONFDIR=$(get_confdir)
 	local i targets currconf
 	targets=( $(find_targets) )
 	[[ -e ${WXCONFFILE} ]] && currconf=$(load_config ${WXCONFFILE} WXCONFIG)
@@ -123,6 +127,7 @@ do_set() {
 	[[ ! -w "${EROOT}"/var/lib/ ]] \
 		&& die -q "You need write permission to /var/lib to perform this action."
 
+	local WXCONFDIR=$(get_confdir)
 	set_config "${1}"
 }
 
@@ -133,6 +138,7 @@ describe_update() {
 do_update() {
 	[[ ! -e ${WXCONFFILE} ]] && do_set none
 
+	local WXCONFDIR=$(get_confdir)
 	currconf=$(load_config ${WXCONFFILE} WXCONFIG)
 
 	# if current config is valid leave it alone