diff --git a/src/http.c b/src/http.c
index 99fa8c0..c01310c 100644
--- a/src/http.c
+++ b/src/http.c
@@ -1517,7 +1517,7 @@ static long op_bio_retry_ctrl(BIO *_b,int _cmd,long _num,void *_ptr){
   return ret;
 }
 
-# if OPENSSL_VERSION_NUMBER<0x10100000L
+# if OPENSSL_VERSION_NUMBER<0x10100000L || LIBRESSL_VERSION_NUMBER<=0x2040100fL
 #  define BIO_set_data(_b,_ptr) ((_b)->ptr=(_ptr))
 #  define BIO_set_init(_b,_init) ((_b)->init=(_init))
 # endif
@@ -1535,7 +1535,7 @@ static int op_bio_retry_free(BIO *_b){
   return _b!=NULL;
 }
 
-# if OPENSSL_VERSION_NUMBER<0x10100000L
+# if OPENSSL_VERSION_NUMBER<0x10100000L || LIBRESSL_VERSION_NUMBER<=0x2040100fL
 /*This is not const because OpenSSL doesn't allow it, even though it won't
    write to it.*/
 static BIO_METHOD op_bio_retry_method={
@@ -1556,7 +1556,7 @@ static BIO_METHOD op_bio_retry_method={
    proxying https URL requests.*/
 static int op_http_conn_establish_tunnel(OpusHTTPStream *_stream,
  OpusHTTPConn *_conn,op_sock _fd,SSL *_ssl_conn,BIO *_ssl_bio){
-# if OPENSSL_VERSION_NUMBER>=0x10100000L
+# if OPENSSL_VERSION_NUMBER>=0x10100000L && !defined(LIBRESSL_VERSION_NUMBER)
   BIO_METHOD *bio_retry_method;
 # endif
   BIO  *retry_bio;
@@ -1569,7 +1569,7 @@ static int op_http_conn_establish_tunnel(OpusHTTPStream *_stream,
   ret=op_http_conn_write_fully(_conn,
    _stream->proxy_connect.buf,_stream->proxy_connect.nbuf);
   if(OP_UNLIKELY(ret<0))return ret;
-# if OPENSSL_VERSION_NUMBER>=0x10100000L
+# if OPENSSL_VERSION_NUMBER>=0x10100000L && !defined(LIBRESSL_VERSION_NUMBER)
   bio_retry_method=BIO_meth_new(BIO_TYPE_NULL,"retry");
   if(bio_retry_method==NULL)return OP_EFAULT;
   BIO_meth_set_write(bio_retry_method,op_bio_retry_write);
@@ -1592,7 +1592,7 @@ static int op_http_conn_establish_tunnel(OpusHTTPStream *_stream,
   /*This shouldn't succeed, since we can't read yet.*/
   OP_ALWAYS_TRUE(SSL_connect(_ssl_conn)<0);
   SSL_set_bio(_ssl_conn,_ssl_bio,_ssl_bio);
-# if OPENSSL_VERSION_NUMBER>=0x10100000L
+# if OPENSSL_VERSION_NUMBER>=0x10100000L && !defined(LIBRESSL_VERSION_NUMBER)
   BIO_meth_free(bio_retry_method);
 # endif
   /*Only now do we disable write coalescing, to allow the CONNECT
@@ -2231,7 +2231,7 @@ static int op_http_stream_open(OpusHTTPStream *_stream,const char *_url,
     /*Initialize the SSL library if necessary.*/
     if(OP_URL_IS_SSL(&_stream->url)&&_stream->ssl_ctx==NULL){
       SSL_CTX *ssl_ctx;
-# if OPENSSL_VERSION_NUMBER<0x10100000L
+# if OPENSSL_VERSION_NUMBER<0x10100000L || LIBRESSL_VERSION_NUMBER<=0x2040100fL
 #  if !defined(OPENSSL_NO_LOCKING)
       /*The documentation says SSL_library_init() is not reentrant.
         We don't want to add our own depenencies on a threading library, and it