--- a/www-apache/mod_perl/mod_perl-2.0.10_pre201601.ebuild	
+++ a/www-apache/mod_perl/mod_perl-2.0.10_pre201601.ebuild	
@@ -14,7 +14,7 @@ SRC_URI="http://dev.gentoo.org/~dilfridge/distfiles/${P}.tar.gz"
 LICENSE="GPL-2"
 SLOT="1"
 KEYWORDS="~alpha amd64 ~arm ~hppa ~ia64 ~ppc ~ppc64 ~sparc ~x86"
-IUSE="debug"
+IUSE="debug ithreads"
 
 # Make sure we always use the latest Apache-Test version or even check the
 # version of the bundled Apache-Test!
@@ -24,7 +24,14 @@ IUSE="debug"
 DEPEND="
 	>=dev-perl/Apache-Test-1.360
 	>=dev-perl/CGI-3.08
-	dev-lang/perl[ithreads]
+	ithreads? (
+		dev-lang/perl[ithreads]
+		www-servers/apache[threads]
+	)
+	!ithreads? (
+		dev-lang/perl
+		www-servers/apache[-apache2_mpms_worker(-)]
+	)
 	www-servers/apache
 "
 RDEPEND="${DEPEND}"
@@ -103,6 +110,7 @@ src_configure() {
 		MP_APR_CONFIG=/usr/bin/apr-1-config \
 		MP_TRACE=${debug} \
 		MP_DEBUG=${debug} \
+		MP_NO_THREADS=$(usex ithreads 0 1) \
 		|| die
 }