--- a/dev-util/boost-build/boost-build-1.52.0-r1.ebuild	
+++ a/dev-util/boost-build/boost-build-1.52.0-r1.ebuild	
@@ -5,7 +5,7 @@ 
 EAPI="5"
 PYTHON_DEPEND="python? 2"
 
-inherit eutils flag-o-matic python toolchain-funcs versionator
+inherit eutils flag-o-matic python toolchain-funcs versionator multilib
 
 MY_PV=$(replace_all_version_separators _)
 
@@ -88,7 +88,10 @@ src_compile() {
 		toolset=cc
 	fi
 
-	CC=$(tc-getCC) ./build.sh ${toolset} -d+2 $(use_with python python "${EROOT}"/usr) || die "building bjam failed"
+	CC=$(tc-getCC) ./build.sh ${toolset} -d+2 \
+		$(use_with python python-include "${EROOT}"usr/include) \
+		$(use_with python python-lib "${EROOT}"usr/$(get_libdir) ) \
+		|| die "building bjam failed"
 }
 
 src_install() {
--