@@ -, +, @@ 
 disable checkboxes properly
---
 source/blender/makesrna/intern/rna_userdef.c       |    7 +++++++
 source/blender/windowmanager/intern/wm_files.c     |    4 ++++
 source/blender/windowmanager/intern/wm_operators.c |   16 ++++++++++++----
 3 files changed, 23 insertions(+), 4 deletions(-)
--- a/source/blender/makesrna/intern/rna_userdef.c	
+++ a/source/blender/makesrna/intern/rna_userdef.c	
@@ -107,6 +107,11 @@ static void rna_userdef_script_autoexec_update(Main *bmain, Scene *scene, Pointe
 	}
 }
 
+static int rna_userdef_script_autoexec_editable(Main *bmain, Scene *scene, PointerRNA *ptr) {
+	/* Disable "Auto Run Python Scripts" checkbox unless Blender run with --enable-autoexec */
+	return !(G.f & G_SCRIPT_OVERRIDE_PREF);
+}
+
 static void rna_userdef_mipmap_update(Main *bmain, Scene *scene, PointerRNA *ptr)
 {
 	GPU_set_mipmap(!(U.gameflags & USER_DISABLE_MIPMAP));
@@ -2508,6 +2513,8 @@ static void rna_def_userdef_system(BlenderRNA *brna)
 	RNA_def_property_boolean_negative_sdna(prop, NULL, "flag", USER_SCRIPT_AUTOEXEC_DISABLE);
 	RNA_def_property_ui_text(prop, "Auto Run Python Scripts", "Allow any .blend file to run scripts automatically (unsafe with blend files from an untrusted source)");
 	RNA_def_property_update(prop, 0, "rna_userdef_script_autoexec_update");
+	/* Disable "Auto Run Python Scripts" checkbox unless Blender run with --enable-autoexec */
+	RNA_def_property_editable_func(prop, "rna_userdef_script_autoexec_editable");
 
 	prop= RNA_def_property(srna, "use_tabs_as_spaces", PROP_BOOLEAN, PROP_NONE);
 	RNA_def_property_boolean_negative_sdna(prop, NULL, "flag", USER_TXT_TABSTOSPACES_DISABLE);
--- a/source/blender/windowmanager/intern/wm_files.c	
+++ a/source/blender/windowmanager/intern/wm_files.c	
@@ -276,6 +276,10 @@ static void wm_init_userdef(bContext *C)
 		else											  G.f &= ~G_SCRIPT_AUTOEXEC;
 	}
 	if(U.tempdir[0]) BLI_where_is_temp(btempdir, FILE_MAX, 1);
+
+	/* Workaround to fix default of "Auto Run Python Scripts" checkbox */
+	if ((G.f & G_SCRIPT_OVERRIDE_PREF) && !(G.f & G_SCRIPT_AUTOEXEC))
+		U.flag |= USER_SCRIPT_AUTOEXEC_DISABLE;
 }
 
 void WM_read_file(bContext *C, const char *name, ReportList *reports)
--- a/source/blender/windowmanager/intern/wm_operators.c	
+++ a/source/blender/windowmanager/intern/wm_operators.c	
@@ -1471,12 +1471,13 @@ static int wm_open_mainfile_exec(bContext *C, wmOperator *op)
 		G.fileflags &= ~G_FILE_NO_UI;
 	else
 		G.fileflags |= G_FILE_NO_UI;
-		
-	if(RNA_boolean_get(op->ptr, "use_scripts"))
+
+	/* Restrict "Trusted Source" mode to Blender in --enable-autoexec mode */
+	if(RNA_boolean_get(op->ptr, "use_scripts") && (!(G.f & G_SCRIPT_OVERRIDE_PREF)))
 		G.f |= G_SCRIPT_AUTOEXEC;
 	else
 		G.f &= ~G_SCRIPT_AUTOEXEC;
-	
+
 	// XXX wm in context is not set correctly after WM_read_file -> crash
 	// do it before for now, but is this correct with multiple windows?
 	WM_event_add_notifier(C, NC_WINDOW, NULL);
@@ -1488,6 +1489,8 @@ static int wm_open_mainfile_exec(bContext *C, wmOperator *op)
 
 static void WM_OT_open_mainfile(wmOperatorType *ot)
 {
+	PropertyRNA * use_scripts_checkbox = NULL;
+
 	ot->name= "Open Blender File";
 	ot->idname= "WM_OT_open_mainfile";
 	ot->description="Open a Blender file";
@@ -1499,7 +1502,12 @@ static void WM_OT_open_mainfile(wmOperatorType *ot)
 	WM_operator_properties_filesel(ot, FOLDERFILE|BLENDERFILE, FILE_BLENDER, FILE_OPENFILE, WM_FILESEL_FILEPATH);
 
 	RNA_def_boolean(ot->srna, "load_ui", 1, "Load UI", "Load user interface setup in the .blend file");
-	RNA_def_boolean(ot->srna, "use_scripts", 1, "Trusted Source", "Allow blend file execute scripts automatically, default available from system preferences");
+	use_scripts_checkbox = RNA_def_boolean(ot->srna, "use_scripts",
+			!!(G.f & G_SCRIPT_AUTOEXEC), "Trusted Source",
+			"Allow blend file execute scripts automatically, default available from system preferences");
+	/* Disable "Trusted Source" checkbox unless Blender run with --enable-autoexec */
+	if (use_scripts_checkbox && (G.f & G_SCRIPT_OVERRIDE_PREF))
+		RNA_def_property_clear_flag(use_scripts_checkbox, PROP_EDITABLE);
 }
 
 /* **************** link/append *************** */
--