--- a/mayavi-3.3.0.ebuild	
+++ a/mayavi-3.3.0.ebuild	
@@ -9,7 +9,7 @@ DESCRIPTION="VTK based scientific data visualizer"
 LICENSE="BSD"
 SLOT="2"
 KEYWORDS="~amd64 ~x86"
-IUSE="doc qt4"
+IUSE="doc qt4 wxpython"
 
 MY_PN="Mayavi"
 MY_P="${MY_PN}-${PV}"
@@ -28,8 +28,9 @@ RDEPEND=">=dev-python/apptools-3.3.0
 	dev-python/ipython
 	>=dev-python/numpy-1.1
 	>=sci-libs/vtk-5[python]
-	dev-python/wxpython:2.8[opengl]
-	qt4? ( dev-python/PyQt4[X,opengl] )"
+        qt4? ( dev-python/PyQt4[X,opengl] )
+	wxpython? ( dev-python/wxpython:2.8[opengl] )
+        !wxpython? ( !qt4? ( dev-python/wxpython:2.8[opengl] ) )"
 
 DEPEND="dev-python/setuptools
 	>=dev-python/numpy-1.1