This patch was taken from gitweb.openembedded.org (Author: Michael 'mickey' Lauer) and
enables the cross compilation of the ctypes module.

diff -Naur Python-2.5.1.orig/setup.py Python-2.5.1/setup.py
--- Python-2.5.orig/setup.py	2006-08-10 01:42:18.000000000 +0200
+++ Python-2.5/setup.py	2007-11-21 18:00:43.000000000 +0100
@@ -1321,16 +1329,16 @@
                                          ffi_configfile):
                 from distutils.dir_util import mkpath
                 mkpath(ffi_builddir)
-                config_args = []
+                config_args = ['--host=%s' % os.environ["CHOST"], ]
 
                 # Pass empty CFLAGS because we'll just append the resulting
                 # CFLAGS to Python's; -g or -O2 is to be avoided.
-                cmd = "cd %s && env CFLAGS='' '%s/configure' %s" \
-                      % (ffi_builddir, ffi_srcdir, " ".join(config_args))
+                cmd = "(cd %s && autoconf -W cross) && (cd %s && env CFLAGS='' '%s/configure' %s)" \
+                      % (ffi_srcdir, ffi_builddir, ffi_srcdir, " ".join(config_args))
 
                 res = os.system(cmd)
                 if res or not os.path.exists(ffi_configfile):
-                    print "Failed to configure _ctypes module"
+                    print "Failed to configure _ctypes module, ret %d or missing %s"% (res, ffi_configfile, )
                     return False
 
             fficonfig = {}
diff -Naur Python-2.5.1.orig/Modules/_ctypes/callbacks.c Python-2.5.1/Modules/_ctypes/callbacks.c
--- Python-2.5.1.orig/Modules/_ctypes/callbacks.c	2006-10-17 21:41:10.000000000 +0200
+++ Python-2.5.1/Modules/_ctypes/callbacks.c	2007-11-22 10:29:33.000000000 +0100
@@ -273,11 +273,13 @@
 		PyErr_NoMemory();
 		return NULL;
 	}
+#if FFI_CLOSURES
 	p->pcl = MallocClosure();
 	if (p->pcl == NULL) {
 		PyErr_NoMemory();
 		goto error;
 	}
+#endif
 
 	for (i = 0; i < nArgs; ++i) {
 		PyObject *cnv = PySequence_GetItem(converters, i);
@@ -315,12 +317,14 @@
 			     "ffi_prep_cif failed with %d", result);
 		goto error;
 	}
+#if FFI_CLOSURES
 	result = ffi_prep_closure(p->pcl, &p->cif, closure_fcn, p);
 	if (result != FFI_OK) {
 		PyErr_Format(PyExc_RuntimeError,
 			     "ffi_prep_closure failed with %d", result);
 		goto error;
 	}
+#endif
 
 	p->converters = converters;
 	p->callable = callable;
@@ -328,8 +332,10 @@
 
   error:
 	if (p) {
+#if FFI_CLOSURES
 		if (p->pcl)
 			FreeClosure(p->pcl);
+#endif
 		PyMem_Free(p);
 	}
 	return NULL;
diff -Naur Python-2.5.1.orig/Modules/_ctypes/_ctypes.c Python-2.5.1/Modules/_ctypes/_ctypes.c
--- Python-2.5.1.orig/Modules/_ctypes/_ctypes.c	2007-03-23 20:56:45.000000000 +0100
+++ Python-2.5.1/Modules/_ctypes/_ctypes.c	2007-11-22 10:29:01.000000000 +0100
@@ -3419,7 +3419,9 @@
 	Py_CLEAR(self->paramflags);
 
 	if (self->thunk) {
+#if FFI_CLOSURES
 		FreeClosure(self->thunk->pcl);
+#endif
 		PyMem_Free(self->thunk);
 		self->thunk = NULL;
 	}
diff -Naur Python-2.5.1.orig/Modules/_ctypes/ctypes.h Python-2.5.1/Modules/_ctypes/ctypes.h
--- Python-2.5.1.orig/Modules/_ctypes/ctypes.h	2006-08-14 13:17:48.000000000 +0200
+++ Python-2.5.1/Modules/_ctypes/ctypes.h	2007-11-22 10:29:44.000000000 +0100
@@ -68,7 +68,9 @@
 };
 
 typedef struct {
+#if FFI_CLOSURES
 	ffi_closure *pcl; /* the C callable */
+#endif
 	ffi_cif cif;
 	PyObject *converters;
 	PyObject *callable;
diff -Naur Python-2.5.1.orig/Modules/_ctypes/malloc_closure.c Python-2.5.1/Modules/_ctypes/malloc_closure.c
--- Python-2.5.1.orig/Modules/_ctypes/malloc_closure.c	2006-06-12 22:56:48.000000000 +0200
+++ Python-2.5.1/Modules/_ctypes/malloc_closure.c	2007-11-22 10:30:17.000000000 +0100
@@ -27,7 +27,9 @@
 /******************************************************************/
 
 typedef union _tagITEM {
+#if FFI_CLOSURES
 	ffi_closure closure;
+#endif
 	union _tagITEM *next;
 } ITEM;