According to https://www.winehq.org/announce/1.9.5 from this version mono 64 should be supported. However the ebuild still checks for the 32 bit version when the mono flag is selected. Output of emerge wine: !!! The ebuild selected to satisfy "app-emulation/wine" has unmet requirements. - app-emulation/wine-1.9.5::gentoo USE="X alsa fontconfig gecko gstreamer jpeg lcms mono mp3 ncurses nls opengl perl png realtime run-exes samba ssl threads truetype udisks xcomposite xinerama xml -capi -cups -custom-cflags -dos -gphoto2 -gsm -ldap -netapi -odbc -openal -opencl -osmesa -oss -pcap -pipelight -prelink -pulseaudio -s3tc -scanner (-selinux) -staging -test -v4l -vaapi" ABI_X86="64 -32 -x32" LINGUAS="en ro -ar -bg -ca -cs -da -de -el -en_US -eo -es -fa -fi -fr -he -hi -hr -hu -it -ja -ko -lt -ml -nb_NO -nl -or -pa -pl -pt_BR -pt_PT -rm -ru -sk -sl -sr_RS@cyrillic -sr_RS@latin -sv -te -th -tr -uk -wa -zh_CN -zh_TW" The following REQUIRED_USE flag constraints are unsatisfied: mono? ( abi_x86_32 ) The above constraints are a subset of the following complete expression: any-of ( abi_x86_32 abi_x86_64 ) test? ( abi_x86_32 ) elibc_glibc? ( threads ) mono? ( abi_x86_32 ) pipelight? ( staging ) s3tc? ( staging ) vaapi? ( staging ) osmesa? ( opengl ) (dependency required by "@selected" [set]) (dependency required by "@world" [argument])
Same issue here..
Resolved in 29ee4ef82bd567b4a270cf923ba28d85f5a202f7