If prelink has been used to prelink the whole system using: $ sudo prelink -avmR Skype 4.0.0.7-r2 does not start because of a segmentation fault at startup. Reinstalling skype solves the issue, prelinking the system again and it segfaults again. Solution: 1) I've created a /etc/env.d/90skype file containing: PRELINK_PATH_MASK=/opt/bin/skype 2) I have reinstalled skype. 3) Prelinked my whole system as usual 4) Skype don't crash anymore I think that this PRELINK_PATH_MASK should be configured by the skype ebuild. Feel free to suggest alternative solution.
Fixed in 4.0.0.8-r1 by installing the env.d file