newer blender results in a completely unfunctional window without the great majority of buttons and menu entries. running it with the debug command line switch on shows that the first error (from which probably the others are derived) is that "bpy: couldnt find 'scripts/modules', blender probably wont start." log to follow Reproducible: Always
Created attachment 318286 [details] blender --debug log
Sigh. And there goes "let's see if it works from commandline and it should do". Okay will set up the environment for it to work properly in -r2.
Fixed in -r2, thanks for reporting.